Study focused on finding rare-variant contributors to Parkinsons' Disease as their low frequency makes them prone to marginalization in summary statistics.
Scoring of individuals in dataset using meta-5 summary statistics. Scoring was done via PRSice. IDs of affected individuals with low PRS scores were stored
Quantile plot generated from PRS Scoring
CADD annotations done via annovar. Coding variants with high CADD scores (i.e., > 12.37) were moved into another file, along with variants annotated as nonsense SNPs, splice site errors, and indels.
Quality-control on ampPD genetic data using PLINK. Filtered out variants with MAF > .05. Reintroduced variants from step 2 into dataset
Rare Variant Analysis done via SkatO
On Genetic Contributers to Early-Onset Alzheimers Disease
Genome-Wide Association aiming to better understand genetic contributors to Early-Onset Alzhemiers Disease. This project focused mostly on rare varaints (i.e., variants with a minor allele frequency less than .05
On Genetic Causes of Parkinsons'
Training study. Genome-wide association study to uncover genetic causes of Parkinsons' disease focusing mostly on common variant contributors.
Drug Discovery '21-'22
Discovery Lab at IMSA focusing on compound growth using ligand-based drug design. PI: Dr. John Thurmond
COVID Moonshot
PostEra crowd sourced project for the discovery of SARS-CoV-2 (CoVid) therapeutics